Copper nanoclusters, thymine-modified hyaluronic acid and poly(copper nanoclusters), method for preparing the same, and application thereof
AssigneeShenzhen Profound-View Pharma Tech Co., Ltd
InventorsTaolei Sun, Baisong Chang
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Abstract
Copper nanoclusters (CuNCs), thymine-modified hyaluronic acid (TMHA), and poly(copper nanoclusters) (PCuNCs) are disclosed. In certain embodiments, the TMHA is represented by formula I, wherein the degree of substitution of thymine in the HA is in a range of 1-50%, and wherein n for GlcA-GlcNAc repeats is an integer, from 10 to 10,000.
Claims13
Copper nanoclusters (CuNCs) modified with one or more ligands, wherein the ligand-modified CuNCs have a diameter in the range of 0.5-5 nm;
- wherein the one or more ligands is (are) selected from the group consisting of, N-isobutyryl-L-cysteine (L-NIBC), N-isobutyryl-D-cysteine (D-NIBC), N-acetyl-D-cysteine, L-cysteine-L-arginine dipeptide (CR), L-arginine-L-cysteine dipeptide (RC), L-cysteine L-histidine (CH), glycine-L-cysteine-L-arginine tripeptide (GCR), L-proline-L-cysteine-L-arginine tripeptide (PCR), glycine-L-serine-L-cysteine-L-arginine tetrapeptide (GSCR) and glycine-L-cysteine-L-serine-L-arginine tetrapeptide (GCSR), and 1-[(2S)-2-methyl-3-thiol-1-oxopropyl]-L-proline.
Thymine-modified hyaluronic acid (TMHA), wherein the TMHA is represented by formula I:
- wherein the degree of substitution of thymine in the HA is in a range of 1-50%, and wherein n for GlcA-GlcNAc repeats is an integer, from 10 to 10,000.
Poly(copper nanoclusters) (PCuNCs), comprising:
- thymine-modified hyaluronic acid (TMHA);
- and
- a plurality of copper nanoclusters (CuNCs);
- wherein the CuNCs are disposed along the TMHA to form the PCuNCs;
- wherein the TMHA is represented by formula I:
- wherein the degree of substitution of thymine in the HA is in a range of 1-50%, and wherein n for GlcA-GlcNAc repeats is an integer, from 10 to 10,000.
Dependencies are inferred from the claim text.