Sample-to-answer microfluidic system and method including vertical microfluidic device and automated actuation mechanisms
AssigneeNovel Microdevices, Inc.
InventorsAndrea Maria Dominic Pais, Rohan Joseph Alexander Pais, Nicholas Watkins, Hamdi Joda
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Abstract
A sample-to-answer microfluidic system and method including vertical microfluidic device and automated actuation mechanisms, such as, but not limited to, automated mechanical and/or magnetic actuation, is disclosed. In some embodiments, the sample-to-answer microfluidic system includes a vertically oriented microfluidic device and a rotating actuator in relation to the microfluidic device, and wherein the microfluidic device and the rotating actuator are operating in the XZ plane. Additionally, methods of using the sample-to-answer microfluidic system are provided.
Claims20
A microfluidic cartridge comprising a primary channel oriented in the XZ plane, a plurality of wells interconnected by said primary channel to form a fluidic circuit, an immiscible reagent container in plane with and fluidly connected to the primary channel and comprising an immiscible reagent, wherein said immiscible reagent container is positioned at a height along a Z axis sufficient to generate a pressure head that drives said immiscible reagent into the microfluidic cartridge from said immiscible reagent container, wherein said microfluidic cartridge is configured to receive magnetic particles and wherein said primary channel is configured such that the magnetic particles are capable of being transferred through said primary channel and resuspended sequentially in said plurality of wells at various stages of operation.
Dependencies are inferred from the claim text.