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US 12,370,521 B2Granted
Row-independent oligonucleotide synthesis
OwnerBruce Erickson, Marshall Henryinventors
Life of this patent
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Abstract
Apparatuses and a method for plate-based oligonucleotide synthesis are disclosed. In one example, an apparatus used in oligonucleotide synthesis includes a machined block to receive a commercially-available synthesis plate. A keeper is used to apply pressure to the commercially-available synthesis plate, and a sealing element is used to seal the commercially-available synthesis plate to the machined block. Other methods and apparatuses are disclosed.
Claims20
An apparatus comprising:
- one or more synthesis plates, each of the one or more synthesis plates having a plurality of rows, each row of the plurality of rows comprising a plurality of wells and each well of the plurality of wells comprising a waste tip;
- a drain block located beneath the one or more synthesis plates;
- and
- a keeper located on top of the one or more synthesis plates, the keeper applying pressure to the one or more synthesis plates, thereby forming a seal around one or both of (i) each of the plurality of rows and (ii) each of the plurality of wells of the one or more synthesis plates.
1 more element
An apparatus comprising:
- a chamber;
- one or more synthesis plates inside the chamber, each of the one or more synthesis plates having a plurality of rows, each row of the plurality of rows comprising a plurality of wells and each well of the plurality of wells comprising a waste tip;
- a drain block located beneath the one or more synthesis plates;
- a keeper located on top of the one or more synthesis plates, the keeper applying pressure to the one or more synthesis plates, thereby forming a seal around one or both of (i) each of the plurality of rows and (ii) each of the plurality of wells of the one or more synthesis plates;
- a plurality of solenoid valves, the plurality of solenoid valves dispensing reagents through the chamber to the plurality of wells of the one or more synthesis plates.
2 more elements
An apparatus comprising:
- a chamber comprising a lid;
- one or more synthesis plates inside the chamber, each of the one or more synthesis plates having a plurality of rows, each row of the plurality of rows comprising a plurality of wells and each well of the plurality of wells comprising a waste tip;
- a drain block located beneath the one or more synthesis plates;
- and
- a keeper located on top of the one or more synthesis plates, the keeper applying pressure to the one or more synthesis plates, thereby forming a seal around one or both of (i) each of the plurality of rows and (ii) each of the plurality of wells of the one or more synthesis plates.
2 more elements
Dependencies are inferred from the claim text.