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US 12,370,272 B2Granted
Gas-filled structures and related compositions, methods and systems to image a target site
AssigneeCalifornia Institute of Technology
InventorsAnupama Lakshmanan, Arash Farhadi, Suchita P. Nety, Raymond W. Bourdeau, Mikhail Shapiro
Life of this patent
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Abstract
Gas vesicles, protein variants and related compositions methods and systems for singleplexed and/or multiplexed ultrasound imaging of a target site in which a gas vesicle provides contrast for the imaging which is modifiable by application of a selectable acoustic collapse pressure value of the gas vesicle.
Claims21
A system for multiplexed ultrasound imaging comprising:
- a first contrast agent comprising a first set of purified gas vesicles (GVs) of a first gas vesicle protein structure (GVPS) type exhibiting a first acoustic collapse pressure profile and a first selectable acoustic collapse pressure value, and
- a second contrast agent comprising a second set of purified GVs of a second GVPS type exhibiting a second acoustic collapse pressure profile and a second selectable acoustic collapse pressure value,
- each GVPS type exhibiting a different acoustic collapse pressure profile defined as a collapse function from which a collapse amount can be determined and a different selectable acoustic collapse pressure value from their corresponding acoustic collapse pressure profile.
Dependencies are inferred from the claim text.