Methods and compositions for producing an adenovirus vector for use with multiple vaccinations
AssigneeEtubics Corporation
InventorsJoseph P. Balint, Frank R. Jones, Richard B. Gayle, III
Life of this patent
Estimating the term…
Abstract
Methods for generating immune responses using adenovirus vectors that allow multiple vaccinations with the same adenovirus vector and vaccinations in individuals with preexisting immunity to adenovirus are provided.
Claims19
A method of treatment for infectious disease or cancer in an individual having pre-existing immunity to an adenovirus and wherein the individual is suffering from or at risk from suffering from an infectious disease or cancer, the method comprising administering an effective amount of a replication defective adenovirus vector two or more times to the individual, wherein the adenoviral vector comprises 1) a deletion in the E2b region and 2) a nucleic acid sequence encoding one or more target antigens, wherein the target antigens comprise infectious disease or cancer associated proteins.
Dependencies are inferred from the claim text.