Microvascular blood flow decreasing agent and use thereof

A method for decreasing blood flow of a microvasculature that is blood vessel(s) which constitutes a microvascular network that is developed de novo in an inflammation site of a subject that has rheumatism, osteoarthropathy, tendinosis, fasciitis, spinal stenosis having chronic pain lasting for three months of longer as chief complaint, and/or various pain regarded as chronic pain syndrome, said method comprising:

• administrating a microvascular blood flow decreasing agent comprising an immune checkpoint inhibitor by injection into an artery responsible for nutrient supply to the inflammation site of the subject in need thereof to decrease blood flow through the microvasculature,
• wherein the immune checkpoint inhibitor is an inhibitor selected from the group consisting of an anti-CTLA-4, anti-PD-1, anti-PD-L1, anti-TIM-3, anti-LAG-3, anti-B7-H3, anti-B7-H4, anti-BTLA, anti-VISTA, and anti-TIGIT antibodies.