Fermentate with anti-inflammatory and immune modulating properties
AssigneeITE Investments, LLC
InventorsMichelle Griffin, Gitte S. Jensen
Life of this patent
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Abstract
A fermentation process is disclosed that produces an immunomodulatory product. The process includes combining a source of starch, a source of sugar, and a source of a trace mineral with probiotic microorganisms and fermenting aerobically and anaerobically, thereby producing an immunomodulatory product. Turmeric is added before or after fermentation. The immunomodulatory product is also disclosed. Also provided are uses of the immunomodulatory product, such as to decrease inflammation in a subject. These methods can include increasing function of natural killer cells, decreasing T cell activation, altering CD69 expression on immune cells, and/or altering cytokine expression in a subject.
Claims15
A method for producing an immunomodulatory product, comprising
- performing steps a-g in order:
- a) preparing a starter culture comprising:
- i) rice bran,
- ii) molasses, and
- iii) a blend of probiotic bacteria and yeast, wherein the blend comprises Lactobacillus acidophilus, Lactobacillus plantarum, Lactobacillus rhamnosus, Lactobacillus fermentum, Lactobacillus casei, Bifidobacterium bifidum, Bifidobacterium longum, Bifidobacterium breve, Bifidobacterium animalis subsp. lactis, Streptococcus thermophilus, Lactococcus lactis, Lactobacillus bulgaricus, and Saccharomyces cerevisiae;
- b) aerobically fermenting the starter culture for about one day, thereby forming an aerobically fermented starter culture;
- c) adding rice bran, molasses, turmeric, and kelp powder to the aerobically fermented starter culture to form a slurry comprising:
- i) 35% to 45% by dry weight rice bran,
- ii) 35% to 45% by dry weight molasses,
- iii) 7.5% to 9% by dry weight turmeric, and
- iv) 4% to 6% by dry weight kelp powder;
- d) aerobically fermenting the slurry for about 6 days, thereby forming an aerobic fermentate;
- e) adding bentonite clay and sea salt to the aerobic fermentate to form an intermediate composition comprising:
- i) 6% to 9% by dry weight bentonite clay, and
- ii) 1% to 2% by dry weight sea salt;
- f) fermenting the intermediate composition anaerobically for about 6 days, thereby forming an anaerobic fermentate;
- and
- g) heating the anaerobic fermentate to about 160 to 170° F. for about 3 to about 5 hours;
- thereby forming the immunomodulatory product.
Dependencies are inferred from the claim text.