Sterile human placental allografts having a plurality of slits, openings, and/or fenestrations formed thereon

A sterile human placental allograft comprising a human amnion layer, an intact human intermediate spongy layer, and a human chorion layer, the sterile human placental allograft comprising interleukin-1 receptor antagonist (IL-1ra) ranging from 1000 to 6000 pg/cm2 and hepatocyte growth factor (HGF) ranging from 600 to 7500 pg/cm2;

• and at least one of the following:
• (a) vascular endothelial growth factor receptor 1 (VEGFR1);
• (b) hyaluronic acid (HA) ranging from 1.0×107 to 1.0×108 pg/cm2;
• (c) platelet derived growth factor subunit B homodimer (PDGF-BB);
• (d) glycosaminoglycans (GAGs);
• (e) collagen;
• and
• (f) exosomes,
• wherein the sterile placental allograft is intact in cross-section in which the human amnion layer and the human chorion layer have an intact human intermediate spongy layer positioned between and connecting the human amnion layer to the human chorion layer, and
• the sterile placental allograft comprises a plurality of flaps formed through the sterile placental allograft, each flap of the plurality of flaps:
• opens by moving in a direction away from the lower surface of the sterile human placental allograft allowing for wound exudate to flow from a wound and passing through the sterile human placental allograft in a direction from a lower surface of the sterile human placental allograft to an upper surface of the sterile human placental allograft to facilitate wound drainage, wound healing, or a combination thereof, and
• closes by moving in a direction towards the lower surface of the sterile human placental allograft such that no opening remains when each flap of the plurality of flaps is closed.