Compositions and methods for treating T cell exhaustion
AssigneeHTYR Acquisition LLC
InventorsYosef Refaeli, Brian C. Turner, Thomas R. Payne
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Abstract
Provided herein are compositions and methods for treating T cell exhaustion in a subject, by administering a PTD-MYC fusion protein (e.g., an HIV TAT-MYC fusion protein) or immune cells treated with a PTD-MYC fusion protein. Kits for use in practicing the methods are also provided herein.
Claims9
A method for treating T cell exhaustion in a subject having a microbial infection, wherein the subject does not have melanoma, comprising administering an effective amount of one or more modified immune cells to the subject, wherein the immune cells are lymphocytes, natural killer cells, myeloid cells, or combinations thereof, and wherein the one or more modified immune cells comprises a MYC fusion protein comprising (i) a protein transduction domain;
- and (ii) a MYC polypeptide, wherein the MYC fusion protein comprises the sequence of SEQ ID:
- NO:
- 1.
Dependencies are inferred from the claim text.