Dietary glycine and serine restriction for cancer treatment
AssigneeRplushealth Limited
InventorsXuelei Ma, Chengyuan He, Zhiwen Long, Zhen Lei
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Abstract
Provided is a food composition that comprises a plurality of amino acids or the salts thereof, wherein the plurality of amino acids or the salts thereof comprise about 0.0016-0.6 wt % of glycine or the salt thereof and about 0.00109-1.2 wt % of serine or the salt thereof. Also provided is a method for treating cancer in a subject in need thereof, comprising partly or completely substituting or replacing the normal diet of the subject with the food composition, and optionally administering to the subject a therapeutically effective amount of an anti-PD-1 antibody or an anti-PD-Li antibody.
Claims18
A pharmaceutical composition, comprising i) a food composition, and ii) an antagonistic anti-PD-1 antibody or an antagonistic anti-PD-L1 antibody,
- wherein the food composition comprises a plurality of amino acids, wherein the plurality of amino acids comprises essential amino acids, 0.0016-0.6 wt % glycine and 0.00109-1.2 wt % serine.
A method for treating cancer in a subject in need thereof, comprising:
- i) partly or completely substituting or replacing normal diet of the subject with a food composition, wherein the food composition comprises i-1) a plurality of amino acids, i-2) one or more macronutrients selected from the group consisting of carbohydrates, fiber and fats, and i-3) one or more micronutrients, wherein the plurality of amino acids comprises essential amino acids, 0.0016-0.6 wt % glycine and 0.00109-1.2 wt % serine, and
- ii) administering to the subject an antagonistic anti-PD-1 antibody or an antagonistic anti-PD-L1 antibody.
Dependencies are inferred from the claim text.