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US 12,370,138 B2Granted
Bioactive granular hydrogel scaffolds and use thereof
AssigneeThe Penn State Research Foundation
InventorsAmir Sheikhi, Arian Jaberi, Mohammad Zaman Ataie
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Abstract
Embodiments relate to a method of forming a granular hydrogel scaffold (GHS). The method comprises converting polymers to form hydrogel microparticles (HMP) via a first crosslinking and assembling the HMP to form GHS via non-light-mediated crosslinking with or without coating or embedding them with any biologies or nanoparticles.
Claims12
A method of forming a granular hydrogel scaffold, the method comprising:
- converting polymers or lipids to form hydrogel microparticles via a first crosslinking;
- injecting the hydrogel microparticles into a tissue;
- assembling the hydrogel microparticles to form the granular hydrogel scaffold via a second crosslinking, wherein the second crosslinking is a non-light-mediated crosslinking;
- and
- mixing the hydrogel microparticles with additional polymers and/or colloidal particles prior to assembling the hydrogel microparticles, wherein the additional polymers are selected from the group consisting of aldehyde-modified carbohydrates, proteoglycans, and mixtures thereof.
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Dependencies are inferred from the claim text.