Device for removing heat, energy, and/or fluid from a living mammal

A device for the treatment of symptoms due to migraine, comprising, in an integrated unit:

• an air delivery subassembly comprising:
• an air inlet,
• an air outlet,
• a first air flow path connecting said air inlet and said air outlet,
• an air inlet sensor(s) configured to measure air flow, temperature, humidity or pressure or any combination of these;
• a blower situated in said first air flow path and configured to draw ambient air from said air inlet and force said ambient air through said first air flow path and out said air outlet,
• an air outlet sensor(s) configured to measure air flow, temperature, humidity or pressure or any combination of these;
• a heat sink situated in said first air flow path, said heat sink having a second air flow path that is not in contact with said first air flow path;
• and
• a liquid delivery subassembly comprising:
• a liquid pump, configured to interface with a liquid supply tube and to force liquid to be drawn into said liquid supply tube from a liquid source and out an outlet of said liquid supply tube,
• said device further comprising
• a manifold air inlet and a manifold air outlet connected by a manifold air flow path, and
• a liquid supply flow path comprising said liquid supply tube attached to and supported in said manifold cartridge and configured to be connected at one end to said liquid source, said liquid supply tube comprising a section of tubing that enters and passes through said manifold air flow path and exits said manifold cartridge through said manifold air outlet.