Back to results
US 12,366,585 B2Granted
Molecular profiling of tumors
AssigneeCaris MPI, Inc.
InventorsDaniel D. Von Hoff, David M. Loesch, Arlet Alarcon, Robert J. Penny, Alan Wright, Matthew J. McGinniss, Ryan P. Bender, Traci Pawlowski
Life of this patent
Estimating the term…
Abstract
Provided herein are methods and systems of molecular profiling of diseases, such as cancer. In some embodiments, the molecular profiling can be used to identify treatments for a disease, such as treatments that were not initially identified as a treatment for the disease or not expected to be a treatment for a particular disease.
Claims20
A computer system, comprising:
- one or more processors;
- and
- computer memory that is in communication with the one or more processors and stores instructions that, when executed by the one or more processors, perform operations comprising:
- obtaining data that is indicative of results of a performance of one or more molecular tests for a plurality of molecular profiling targets of a biological sample obtained from a patient that has a particular cancer type, wherein the one or more molecular tests comprises at least one selected from a group consisting of gene expression analysis and nucleic acid sequence analysis;
- accessing, without using the particular cancer type, a first database of the computer system to obtain corresponding reference values;
- comparing the obtained data to the corresponding reference values obtained from the first database of the computer system, wherein the corresponding reference values are not associated with the particular cancer type in the first database as part of the comparing;
- accessing, without using the particular cancer type, the first database or another database to identify, from the comparing, at least one therapeutic agent based on an indication that the comparison indicates a likely benefit to the patient of the at least one therapeutic agent;
- generating a patient profile report that presents the identified at least one therapeutic agent as a suitable agent for the patient, wherein the least one therapeutic agent includes a treatment not associated with treating the particular cancer type;
- and
- providing the patient profile report to an end user.
7 more elements
A method, comprising:
- obtaining, by a computer system, data that is indicative of results of a performance of one or more molecular tests for a plurality of molecular profiling targets of a biological sample obtained from a patient that has a particular cancer type;
- comparing, by the computer system, the obtained data to corresponding reference values stored in a database of the computer system, wherein the corresponding reference values are not associated with the particular cancer type in the database as part of the comparing;
- identifying, from the comparing by the computer system, at least one therapeutic agent based on an indication that the comparison indicates a likely benefit to the patient of the at least one therapeutic agent, wherein the identifying is performed without using the particular cancer type;
- generating, by the computer system, a patient profile report that presents the identified at least one therapeutic agent as a suitable agent for the patient;
- and
- administering at least of the at least one therapeutic agent to the patient, wherein the administered at least one therapeutic agent includes a therapeutic agent selected from a chemotherapeutic or hormonal treatment regimen.
3 more elements
One or more non-transitory computer-readable storage medium storing instructions that, when executed by one or more computers, cause the one or more computers to perform operations, the operations comprising:
- obtaining data that is indicative of results of a performance of one or more molecular tests for a plurality of molecular profiling targets of a biological sample obtained from a patient that has a particular cancer type;
- accessing, without using the particular cancer type, a database of the one or more computers to obtain corresponding reference values;
- comparing the obtained data to the corresponding reference values obtained from the database of the one or more computers, wherein the corresponding reference values are not associated with the particular cancer type in the database as part of the comparing;
- accessing, without using the particular cancer type, the database or another database to identify, from the comparing, at least one therapeutic agent based on an indication that the comparison indicates a likely benefit to the patient of the at least one therapeutic agent;
- generating a patient profile report that presents the identified at least one therapeutic agent as a suitable agent for the patient, wherein the least one therapeutic agent includes a treatment not associated with treating the particular cancer type;
- and
- providing the patient profile report to an end user.
4 more elements
Dependencies are inferred from the claim text.