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US 12,366,582 B2Granted
Collagen type X alpha-1 assay
AssigneeNordic Bioscience A/S
InventorsYi He, Anne-Cecilie Bay-Jensen, Morten Karsdal
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Abstract
Provided herein is an antibody specifically reactive with an N-terminus neo-epitope of collagen type X alpha 1 in the amino acid sequence H2N-GIATKGLNGP, and its use in an immunoassay for evaluating a disease associated with collagen type X alpha 1, such as osteoarthritis.
Claims13
An antibody, wherein said antibody specifically reacts with an N-terminus neo-epitope of collagen type X alpha 1 comprised in the amino acid sequence H2N-GIATKGLNGP (SEQ ID NO:
- 1);
- wherein the antibody comprises complementarity-determining regions (CDRs):
- CDR-L1:
- RSSQSLVHNNGNTYLH (SEQ ID NO:
- 13),
- CDR-L2:
- KVSNRFS (SEQ ID NO:
- 14),
- CDR-L3:
- SQITHVPWT (SEQ ID NO:
- 15),
- CDR-H1:
- SGFWS (SEQ ID NO:
- 16),
- CDR-H2:
- YIKYSGDTYFNPSLKS (SEQ ID NO:
- 17), and
- CDR-H3:
- MDY (SEQ ID NO:
- 24).
17 more elements
Dependencies are inferred from the claim text.