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US 12,366,548 B2Granted
Analyte sensor
AssigneeDexCom, Inc.
InventorsTed Tang Lee, Andrew Trinin Dennis, Shanger Wang, Jiong Zou
Life of this patent
Estimating the term…
Abstract
Disclosed are devices for determining an analyte concentration. The devices comprise a sensor configured to generate a signal associated with a concentration of an analyte and an electronics unit operatively connected to the sensor. The electronics unit may be engaged with a housing that may secure the device to a host's skin. In this regard, in one embodiment, the housing may be attached to an adhesive patch that is fastened to the skin of the host.
Claims23
A device for measurement of a concentration of an analyte, the device comprising:
- a sensor having a sensing region and configured to generate a signal associated with the concentration of the analyte;
- and
- a sensing membrane located over the sensor, the sensing membrane comprising a biointerface layer positioned most distally to the sensing region such that its outermost domain contacts a biological fluid when inserted in vivo, wherein the biointerface layer comprises a biointerface polymer, wherein the biointerface polymer comprises polyurethane and/or polyurea segments and one or more zwitterions forming repeating units in a polymer backbone;
- wherein the one or more zwitterions are derived from a monomer selected from the group consisting of:
- where Z is branched or straight chain alkyl, heteroalkyl, cycloalkyl, cycloheteroalkyl, aryl, or heteroaryl;
- R1 is H, alkyl, heteroalkyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl;
- and R2, R3, and R4 are independently chosen from alkyl, heteroalkyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl;
- and wherein two or more of R1, R2, R3, R4, and Z are substituted with a polymerization group;
- or
- wherein the one or more zwitterions are derived from a monomer selected from the group consisting of:
- where Z is branched or straight chain alkyl, heteroalkyl, cycloalkyl, cycloheteroalkyl, aryl, or heteroaryl;
- R1 is H, alkyl, heteroalkyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl;
- and R2 and R3, are independently chosen from alkyl, heteroalkyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl;
- wherein two or more of R1, R2, R3, and Z are substituted with a polymerization group;
- or
- wherein the one or more zwitterions are derived from a monomer selected from the group consisting of:
- where Z is branched or straight chain alkyl, heteroalkyl, cycloalkyl, cycloheteroalkyl, aryl, or heteroaryl;
- R1 is H, alkyl, heteroalkyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl;
- and R2 and R3 are independently chosen from alkyl, heteroalkyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl;
- wherein two or more of R1, R2, R3, and Z are substituted with a polymerization group.
17 more elements
A device for the continuous measurement of a concentration of glucose, the device comprising:
- a sensor having an electrode including a sensing region and configured to generate a signal associated with the concentration of the glucose;
- and
- a sensing membrane located over the sensor, the sensing membrane comprising a biointerface layer positioned most distally to the sensing region such that its outermost domain contacts a biological fluid when inserted in vivo, wherein the biointerface layer comprises a biointerface polymer, wherein the biointerface polymer comprises polyurethane and/or polyurea segments and one or more zwitterions forming repeating units in a polymer backbone;
- wherein the one or more zwitterions are derived from a monomer selected from the group consisting of:
- where Z is branched or straight chain alkyl, heteroalkyl, cycloalkyl, cycloheteroalkyl, aryl, or heteroaryl;
- R1 is H, alkyl, heteroalkyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl;
- and R2, R3, and R4 are independently chosen from alkyl, heteroalkyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl;
- and wherein two or more of R1, R2, R3, R4, and Z are substituted with a polymerization group;
- or
- wherein the one or more zwitterions are derived from a monomer selected from the group consisting of:
- where Z is branched or straight chain alkyl, heteroalkyl, cycloalkyl, cycloheteroalkyl, aryl, or heteroaryl;
- R1 is H, alkyl, heteroalkyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl;
- and R2 and R3, are independently chosen from alkyl, heteroalkyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl;
- wherein two or more of R1, R2, R3, and Z are substituted with a polymerization group;
- or
- wherein the one or more zwitterions are derived from a monomer selected from the group consisting of:
- where Z is branched or straight chain alkyl, heteroalkyl, cycloalkyl, cycloheteroalkyl, aryl, or heteroaryl;
- R1 is H, alkyl, heteroalkyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl;
- and R2 and R3 are independently chosen from alkyl, heteroalkyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl;
- wherein two or more of R1, R2, R3, and Z are substituted with a polymerization group.
17 more elements
A device for measurement of a concentration of an analyte, the device comprising:
- a sensor having a sensing region and configured to generate a signal associated with the concentration of the analyte;
- and
- a sensing membrane located over the sensor, the sensing membrane comprising a biointerface layer positioned most distally to the sensing region such that its outermost domain contacts a biological fluid when inserted in vivo, wherein the biointerface layer comprises a biointerface polymer, wherein the biointerface polymer comprises polyurethane and/or polyurea segments and one or more carboxyl betaine zwitterions forming repeating units in a polymer backbone;
- wherein the one or more carboxyl betaine zwitterions are derived from a monomer including two or more polymerization groups selected from alkene, alkyne, epoxide, lactone, amine, hydroxyl, isocyanate, carboxylic acid, anhydride, silane, halide, aldehyde, and carbodiimide;
- wherein the biointerface polymer further comprises at least one segment selected from the group consisting of epoxides, polyolefins, polysiloxanes, polyamide, polystyrene, polyacrylate, polyethers, polyesters, and polycarbonates.
2 more elements
Dependencies are inferred from the claim text.