Adenoviral vector
AssigneeOxford University Innovation Limited
InventorsSarah C. Gilbert, Adrian V S Hill, Matthew G. Cottingham, Matthew Dicks, Susan J. Morris, Alexander Douglas
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Abstract
The present invention provides recombinant adenoviral vectors, immunogenic compositions thereof and their uses in medicine. In particular, the present invention provides an adenoviral vector comprising the genome of an adenovirus other than AdHu5 and AdY25, wherein the genome of the adenovirus has been modified such that the vector lacks the native E4 locus of the adenovirus and comprises heterologous E4Orf1, E4Orf2 and E4Orf3 coding regions from AdY25.
Claims21
An adenoviral vector comprising the genome of chimpanzee adenovirus C68, wherein the genome of the adenovirus has been modified such that the vector lacks the native E4 locus of the C68 adenovirus and comprises heterologous E4Orf1, E4Orf2 and E4Orf3 coding regions from AdY25, and wherein the adenovirus further comprises heterologous E4Orf4, E4Orf6 and E4Orf6/7 coding regions from AdHu5 in the E4 locus of the adenovirus, and wherein said adenoviral vector lacks a functional E1 locus, and wherein said adenoviral vector lacks an E3 locus, and wherein the adenoviral vector comprises bacteriophage lambda site specific recombination sites at the E1 locus.
An adenoviral vector comprising the genome of chimpanzee adenovirus C68,
- wherein the genome of the adenovirus has been modified such that the vector lacks the native E4 locus of the C68 adenovirus and comprises heterologous E4Orf1, E4Orf2 and E4Orf3 coding regions from AdY25,
- wherein the adenovirus further comprises heterologous E4Orf4, E4Orf6 and E4Orf6/7 coding regions from AdHu5 in the E4 locus of the adenovirus,
- wherein said adenoviral vector lacks a functional E1 locus,
- wherein said adenoviral vector lacks an E3 locus,
- wherein the adenoviral vector comprises bacteriophage lambda site specific recombination sites at the E1 locus, and
- wherein the bacteriophage lambda site specific recombination sites are attR1 and attR2.
An adenoviral vector comprising the genome of chimpanzee adenovirus C68,
- wherein the genome of the adenovirus has been modified such that the vector lacks the native E4 locus of the C68 adenovirus and comprises heterologous E4Orf1, E4Orf2 and E4Orf3 coding regions from AdY25,
- wherein the adenovirus further comprises heterologous E4Orf4, E4Orf6 and E4Orf6/7 coding regions from AdHu5 in the E4 locus of the adenovirus,
- wherein said adenoviral vector lacks a functional E1 locus,
- wherein said adenoviral vector lacks an E3 locus,
- wherein the adenoviral vector comprises bacteriophage lambda site specific recombination sites at the E1 locus, and
- wherein the vector comprises the polynucleotide sequence of SEQ ID NO:
- 10.
Dependencies are inferred from the claim text.