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US 12,365,880 B2Granted
Recombinant influenza viruses with stabilized NA
AssigneesThe University of Tokyo, Wisconsin Alumni Research Foundation (WARF)
InventorsYoshihiro Kawaoka, Yuri Furusawa, Seiya Yamayoshi
Life of this patent
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Abstract
Modified influenza virus neuraminidases are described herein that have stabilized NA tetramers which may improve vaccine production efficiency, thus improving the yield of vaccine viruses.
Claims17
A method of immunizing an avian or a mammal, comprising:
- administering to the avian or the mammal a composition having an effective amount of an isolated recombinant influenza virus comprising stabilized neuraminidase (NA) tetramers and a NA viral segment encoding a modified NA monomer that forms virions having the stabilized NA tetramers relative to a corresponding influenza virus having a parental NA viral segment encoding an unmodified NA monomer, wherein the modified NA monomer comprises a modified NA stalk that results in the stabilized NA tetramers, wherein the modified NA has a cysteine at position 48 or position 50 or both positions of 48 and 50 relative to the numbering of NA1 of SEQ ID NO:37.
Dependencies are inferred from the claim text.