Methods and products for genetic engineering
AssigneesInstitut National De La Sante Et De La Recherche Medicale (Inserm), Centre National de la Recherche Scientifique (CNRS), Ecole Normale Superieure de Lyon Lyon, Universite Claude Bernard Lyon
InventorsThéophile Ohlmann, Philippe Mangeot, Emiliano Ricci
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Abstract
The present invention relates to a virus-derived particle comprising one or more Cas protein(s), as well as to kits and methods using the same for altering a target nucleic acid.
Claims20
A retrovirus-derived particle comprising one or more Cas protein(s), wherein the one or more Cas protein(s) is inside of the particle, wherein the one or more Cas protein(s) inside of the particle is the result of cleavage of a cleavable fusion protein comprising a proteolysis cleavage site located between one or more Cas proteins and a retroviral gag protein, and wherein the one or more Cas protein(s) is complexed with one or more CRISPR-Cas guide RNA(s).
Dependencies are inferred from the claim text.