Stable heavy isotopes in amide functional groups and uses thereof
AssigneesRisen (Suzhou) Pharma Tech Co., Ltd., Shanghai Junshi Biosciences Co., Ltd.
InventorsJiasheng Lu, Jiamin Gu, Xiang Ji, Dongqing Zhu, Xiaolin He, Xianqi Kong
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Abstract
There are provided isotope-enriched compounds containing stable heavy isotope-enriched amide functional groups for modulating the pharmacokinetic profile, metabolic profile, and/or delivery efficiency of a drug or prodrug, as well as its therapeutic or prophylactic efficacy and/or adverse effects. Use of the isotope-enriched amide-containing drugs and prodrugs for the treatment or prevention of disease states and conditions is also provided.
Claims20
An isotope-enriched compound of Formula II, or a pharmaceutically acceptable salt, ester, hydrate, chelate, or solvate thereof:
- where:
- is an amide functional group isotope-enriched with one or more stable heavy isotope selected from 18O, 17O, 13C, and 15N;
- and
- R1 and R2 are independently a hydrogen or a protecting group selected from acyl, carbonyl, thiocarbonyl, and carbamoyl groups.
Dependencies are inferred from the claim text.