Nitrile derivative that acts as inhibitor of dipeptidyl peptidase 1 and use thereof

A compound of formula (III), or a stereoisomer, a deuterated product, a solvate or a pharmaceutically acceptable salt thereof:

• wherein Rc is H, ═O, halogen, cyano, hydroxyl, NH2, —COOH, C1-4 alkyl, halo C1-4 alkyl, hydroxy C1-4 alkyl, C1-4 alkoxy, C1-6 alkoxyalkyl, or halo C1-4 alkoxy;
• R1, R2, and R3 are each independently selected from H, deuterium, halogen, C1-4 alkyl, and C1-4 alkoxy, and the alkyl and alkoxy are optionally substituted with 1-3 groups selected from halogen, C1-4 alkyl, cyano, hydroxyl, NH2, and COOH;
• optionally, R1 and R2 together with the carbon atom to which they are attached form C3-6 cycloalkyl, and the cycloalkyl is optionally substituted with 1-3 groups selected from halogen, cyano, hydroxyl, NH2, COOH, and C1-4 alkyl;
• L1 is a bond;
• ring G is a benzene ring, optionally substituted with 1-3 RG groups, or
• and L1 is attached to the ring G by replacing any hydrogen atom on the ring atoms;
• each R4 is independently selected from H, halogen, C1-4 alkyl, C1-4 alkoxy, C2-6 alkenyl, C2-6 alkynyl, C3-6 cycloalkyl, cyano, hydroxyl, and NH2;
• the alkyl, alkenyl, alkynyl, and cycloalkyl in the case of R4 are optionally substituted with 1-3 groups selected from deuterium and halogen,
• each RG is independently selected from deuterium, SF5, halogen, cyano, hydroxyl, NH2, C1-4 alkyl, and the RG is optionally further substituted with 1-3 groups selected from deuterium and halogen;
• X1, X2, X3, and X4 are each independently selected from a bond, NR5, O, CR6R7, S, S(O), and S(O)2, and at most one of X1, X2, X3, and X4 is a bond;
• each R5 is independently selected from H, C1-4 alkyl, and C3-6 cycloalkyl, wherein the alkyl and cycloalkyl are optionally substituted with 1-3 groups selected from deuterium, halogen, cyano, hydroxyl, NH2, and COOH;
• R6 and R7 are each independently selected from H, deuterium, halogen, C1-4 alkyl, and C1-4 alkoxy, wherein the alkyl and alkoxy are optionally substituted with 1-3 groups selected from deuterium, halogen, cyano, hydroxyl, NH2, and COOH;
• optionally, R6 and R7 form ═O;
• optionally, two R5 on adjacent ring atoms, two R6 on adjacent ring atoms, or R5 and R6 on adjacent ring atoms in X1, X2, X3, and X4 together with the atoms to which they are attached form a double bond;
• provided that:
• (1) A is
• and ring A is optionally substituted with 1-3 R8 groups;
• each R8 is independently selected from halogen, cyano, hydroxyl, NH2, —COOH, C1-4 alkyl, C2-6 alkenyl, C2-6 alkynyl, and C3-6 cycloalkyl;
• * indicates the end connected to the alkyl carbon atom;
• or
• (2) A is
• wherein * indicates the end connected to the alkyl carbon atom;
• RA1, RA2, RA3, and RA4 are each independently R8, and RA1, RA2, RA3, and RA4 are not H at the same time;
• and each R8 is independently selected from H, deuterium, halogen, C1-4 alkyl, C1-4 alkoxy, cyano, hydroxyl, NH2, and COOH, wherein the alkyl and alkoxy are optionally substituted with 1-3 groups selected from deuterium, halogen, cyano, hydroxyl, NH2, and COOH.