Treprostinil derivative compounds and methods of using same

A compound of Formula I or a pharmaceutically acceptable salt, polymorph or stereoisomer thereof:

• wherein:
• R20, R21, R22, R23, R24, R25, R26, R27, R28, R29, R30, R31, R32, R33, R34, R35, and R36 are independently H or deuterium;
• Z is —OR11, wherein R11 is branched alkyl, haloalkyl, halocycloalkyl, heteroalkyl, substituted heteroalkyl, cycloheteroalkyl, substituted cycloheteroalkyl, bicycloalkyl, alkylcycloalkyl, substituted alkylcycloalkyl, alkylcycloheteroalkyl, substituted alkylcycloheteroalkyl, alkylaryl, substituted alkylaryl, alkylheteroaryl, substituted alkylheteroaryl, heteroaryl, or substituted heteroaryl, wherein unsubstituted or substituted heteroalkyl is not an unsubstituted or substituted monovalent saturated hydrocarbon group attached to a nitrogen atom, and wherein unsubstituted or substituted alkylaryl is not unsubstituted or substituted benzyl;
• and
• R1 and R2 are independently H or P2, wherein P2 is selected from the group consisting of:
• wherein:
• m is 1, 2, 3, or 4;
• and
• R14 is independently in each occurrence selected from the group consisting of H, alkyl, cycloalkyl, alkylcycloalkyl, haloalkyl, heteroalkyl, substituted alkyl, aryl, heteroaryl, arylalkyl, heteroarylalkyl, substituted aryl, substituted heteroaryl, substituted arylalkyl, and substituted heteroarylalkyl.