Process for 4-(hydroxymethyl)-5-methyl-1,3-dioxol-2-one
AssigneePiramal Pharma Limited
InventorsChangdev Raut, Ajay Kumbhar, Tanaji Jadhav, Ganesh Wagh, Ashutosh Jagtap, Sivakumar Rallapalli
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Abstract
The present invention relates to an improved process for 4-(Hydroxymethyl)-5-methyl-1,3-dioxol-2-one (I). The process involves reaction of compound of formula (II) with sodium acetate in presence of catalytic amount of potassium iodide in dimethyl formamide solvent at 25-30° C. to give 5-methyl-2-oxo-1,3-dioxol-4-yl)methyl acetate (IV) which was further Acid hydrolysed by IPA·HCl in Isopropyl alcohol solvent to yield 4-(hydroxymethyl)-5-methyl-1,3-dioxol-2-one (I).
Claims10
An improved process for the preparing 4-(Hydroxymethyl)-5-methyl-1,3-dioxol-2-one (I),
- comprising;
- (a) reacting compound of formula (II) with alkali metal acetate in a solvent and optionally in presence of a catalyst to obtain (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl acetate (IV), and optionally isolating compound of formula (IV);
- (b) treating the compound of formula (IV) with an acid solution in a solvent to produce 4-(Hydroxymethyl)-5-methyl-1,3-dioxol-2-one (I).
An improved process for the preparation of 4-(Hydroxymethyl)-5-methyl-1,3-dioxol-2-one (I),
- comprising;
- (a) reacting compound of formula (II) with alkali metal acetate in a solvent and optionally in presence of a catalyst to obtain (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl acetate (IV);
- wherein, the said reaction is carried out at a temperature in the range of 25° C. to 35° C.;
- (b) treating the compound of formula (IV) with an acid solution in a solvent to produce 4-(Hydroxymethyl)-5-methyl-1,3-dioxol-2-one (I).
Dependencies are inferred from the claim text.