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US 12,365,657 B2Granted
Preparation of 2-chloro-1-(2-chlorothiazol-5-yl)ethanone
AssigneeBASF SE
InventorsHarish Shinde, Rahul Kaduskar, Christopher Koradin, Martin John McLaughlin, Roland Goetz, Sunil Khamkar
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Abstract
The present invention relates to a process for the preparation 2-chloro-1-(2-chlorothiazol-5-yl)ethanone.
Claims13
A process for the preparation of 2-chloro-1-(2-chlorothiazol-5-yl)ethanone comprising:
- a) cyclization of 1,3-bis(dimethylaminomethylene)thiourea and chloroacetone to form N′-(5-acetylthiazol-2-yl)-N,N-dimethyl-formamidine,
- b) subjecting (5-acetylthiazol-2-yl)-N,N-dimethyl-formamidine to at least one acid to form 1-(2-aminothiazol-5-yl)ethanone,
- c) Sandmeyer reaction of 1-(2-aminothiazol-5-yl)ethanone to form 1-(2-chlorothiazol-5-yl)ethanone, and
- d) chlorination of 1-(2-chlorothiazol-5-yl)ethanone to form 2-chloro-1-(2-chlorothiazol-5-yl)ethanone,
- wherein in step a) chloroacetone is added at a rate in a range of ≥2.0 vol.-%/minute to ≤8.0 vol.-%/minute, based on the total volume of chloroacetone.
2 more elements
Dependencies are inferred from the claim text.