Multiplex synthesis method of compound library and parallel synthesizer of compound library using same
AssigneePostech Research and Business Development Foundation
InventorsDong Pyo Kim, Gwang Noh Ahn
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Abstract
The present invention relates to a parallel synthesis method and synthesizer of a compound library, and more specifically provides a parallel synthesis method and synthesizer of a compound library, which uniformly distribute a first reactant and perform independent reactions in separate spaces, and since it is possible to confirm the results for various reaction variables at once, the synthesis time of the compound library can be reduced with a high synthesis yield of the product.
Claims10
A parallel synthesizer of a compound library, comprising:
- a first inlet unit through which a first reactant is introduced and at least one inlet is formed;
- a flow distributor connected to the first inlet unit and distributing the introduced first reactant in equal amounts, and formed with a damper and a baffle;
- a plurality of ducts connected to the flow distributor and through which the distributed first reactant passes, respectively;
- a second inlet unit located at one side of the ducts and formed with an inlet through which a second reactant is introduced;
- a plurality of reactors respectively connected to the ducts and in which a product is generated by a chemical reaction of the first reactant and the second reactant transported through the ducts;
- and
- a discharge unit formed on one side of the reactors to discharge the product,
- wherein the temperature and time of the chemical reaction can be independently controlled in each of the reactors,
- wherein each of the ducts is a coiled capillary thinner than the connected reactors, and
- wherein a flow velocity in the ducts is 0.3 to 0.5 mL/min.
A parallel synthesizer of a compound library, comprising:
- a first inlet unit through which a first reactant is introduced and at least one inlet is formed;
- a flow distributor connected to the first inlet unit and distributing the introduced first reactant in equal amounts, and formed with a damper and a baffle;
- a plurality of ducts connected to the flow distributor and through which the distributed first reactant passes, respectively;
- a second inlet unit located at one side of the ducts and formed with an inlet through which a second reactant is introduced;
- a plurality of reactors respectively connected to the ducts and in which a product is generated by a chemical reaction of the first reactant and the second reactant transported through the ducts;
- and
- a discharge unit formed on one side of the reactors to discharge the product,
- wherein the temperature and time of the chemical reaction can be independently controlled in each of the reactors,
- wherein each of the ducts is a coiled capillary thinner than the connected reactors,
- wherein a flow velocity in the ducts is 0.3 to 0.5 mL/min,
- wherein the first reactant is an aryldiazonium salt, and
- wherein the aryldiazonium salt comprises a cation represented by Chemical Formula 1 below:
- In Chemical Formula 1 above, R is hydrogen, a hydroxyl group, an ether group, a halogen atom, a carbonyl group, a nitro group, a naphthyl group, a cyano group, an amino group, an amidino group, hydrazine, hydrazone, a carboxyl group, a sulfonic acid group, a phosphoric acid group, an alkyl group having 1 to 12 carbon atoms, an alkenyl group having 1 to 12 carbon atoms, an alkynyl group having 1 to 12 carbon atoms, an aryl group having 6 to 10 carbon atoms, or an arylalkyl group having 7 to 10 carbon atoms.
Dependencies are inferred from the claim text.