Tangential flow filter system for the filtration of materials from biologic fluids
AssigneeMinnetronix, Inc.
InventorsEmily Rolfes Meyering, Gary Seim, Abhi Vase, Ben Krehbiel, Blake Hedstrom, Aaron McCabe
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Abstract
Systems and methods for filtering materials from biologic fluids are discussed. Embodiments may be used to filter cerebrospinal fluid (CSF) from a human or animal subject. The method may include the steps of withdrawing fluid comprising CSF, filtering the volume into permeate and retentate by passing the fluid through a tangential flow filter, and returning the permeate to the subject. During operation of the system, various parameters may be modified, such as flow rate.
Claims10
A system for filtering materials from cerebrospinal fluid (CSF) of a human or animal subject, the system comprising:
- a filtration system, the filtration system including a multi-lumen catheter, a pump, a first filter, a second filter, and a combiner;
- a processor coupled to the filtration system;
- wherein the multi-lumen catheter is configured to be inserted at least partially into a CSF-containing space of a subject for withdrawing a first volume of a fluid comprising CSF from the CSF-containing space of the subject at a first flow rate through a first lumen formed in the multi-lumen catheter;
- wherein the filtration system is configured to operate according to a set of operation parameters;
- wherein the first filter includes a tangential flow filter for filtering the first volume of the fluid into a first permeate and a first retentate;
- wherein the second filter is configured to filter the first retentate into a second permeate and a second retentate;
- wherein the combiner is configured to combine the first permeate with the second permeate to form a combined permeate;
- wherein the filtration system includes one or more sensors for measuring the first volume, a volume of the combined permeate, and a difference between the first volume and a volume of the combined permeate;
- wherein the multi-lumen catheter is designed to return the combined permeate through a second lumen formed in the multi-lumen catheter to the CSF-containing space of the subject at a second flow rate;
- and
- wherein the processor is configured to update a parameter of the set of operation parameters when the difference between the first volume and the volume of the combined permeate exceeds a predetermined threshold.
Dependencies are inferred from the claim text.