Apparatus for removing chemotherapy compounds from blood
AssigneeDelcath Systems, Inc.
InventorsDaniel S. Johnston, Jacques Chammas, William M. Appling, Samantha J. Barton
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Abstract
A filter apparatus for removing small molecule chemotherapy agents from blood is provided. The filter apparatus comprises a housing with an extraction media comprised of polymer coated carbon cores. Also provided are methods of treating a subject with cancer of an organ or region comprising administering a chemotherapeutic agent to the organ or region, collecting blood laded with chemotherapeutic agent from the isolated organ, filtering the blood laden with chemotherapeutic agent to reduce the chemotherapeutic agent in the blood and returning the blood to the subject.
Claims26
An extraction media comprising:
- hemocompatible polymer coated carbon cores, the carbon cores having a pore volume of 1.68 cc/g to 2.19 cc/g and an apparent density of 0.185 g/cc to 0.195 g/cc, and
- wherein the hemocompatible polymer is a semipermeable polymer selected from a group consisting of cellulose, a methacrylate polymer and combinations thereof.
A filter cartridge comprising a housing having an inlet and an outlet and an extraction media comprising hemocompatible polymer coated carbon cores contained within the housing, wherein the carbon cores have a pore volume of 1.68 cc/g to 2.19 cc/g and an apparent density of 0.185 g/cc to 0.195 g/cc.
A two filter cartridge comprising two filter cartridges arranged in parallel, wherein each of the filter cartridges comprises a housing having an inlet and an outlet and an extraction media comprising hemocompatible polymer coated carbon cores contained within the housing, wherein the carbon cores have a pore volume of about 1.68 cc/g to about 2.19 cc/g.
A two filter cartridge according 14, wherein the semipermeable polymer coating is a methacrylate selected from the group consisting of polymethylmethacrylate (PMMA), polyethylmethacrylate (PEMA), polyhydroxyethyl-methacrylate (PHEMA), and combinations thereof.
A kit of parts capable of being assembled for delivering a small molecule chemotherapeutic agent to a liver of a subject, comprising:
- a double balloon catheter and a dual filter apparatus comprising two filter cartridges arranged in parallel, wherein each of the filter cartridges comprises a housing having an inlet and an outlet and an extraction media comprising hemocompatible polymer coated carbon cores contained within the housing, wherein the carbon cores have a pore volume of about 1.68 cc/g to about 2.19 cc/g.
Dependencies are inferred from the claim text.