Enzymes entrapped in organopolysiloxane matrix for treating intestinal diseases

One or more quorum silencing enzymes entrapped in an organopolysiloxane matrix assembled in situ, wherein:

• the quorum silencing enzymes are an acyl-homoserine lactone hydrolase;
• and
• the organopolysiloxane matrix comprises tetra-alkoxy siloxane moieties, trialkoxy-organosiloxane moieties, or a combination thereof, wherein the organopolysiloxane matrix is obtained by gelating a hydrolyzed siloxane pre-polymer mixture having a ratio of 60-70 mol % of one or more tetraalkoxysilane monomers having the general formula Si(OR)4 to 40-30 mol % of one or more trialkoxy-organosiloxane monomers having the general formula Si(OR)3R′, wherein each R group is independently selected from the group consisting of methyl, ethyl, propyl, isopropyl, and butyl alkyl, and each R′ group is independently selected from the group consisting of methyl, ethyl, propyl, isopropyl, butyl, octyl, hexadecyl, octadecyl, phenyl, trimethylaminopropyl, aminopropyl, aminobutyl, alkyl, mercaptopropyl, and methylphosphonyl;
• and
• the quorum silencing enzymes and the hydrolyzed siloxane pre-polymer are at a molar ratio in a range from 1:1000 to 1:1, respectively.