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US 12,364,733 B1Granted
Method for treating septic shock
AssigneeInotrem
InventorsMarc Derive, Aurelie Olivier, Kevin Carrasco, Martin Koch, Margarita Salcedo-Magguilli, Amir Boufenzer, Lucie Jolly, Jean-Jacques Garaud
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Abstract
The present disclosure relates to a method of treating an acute inflammatory disorder such as septic shock in a subject in need thereof. The method involves administering to a subject who has a soluble TREM-1 (sTREM-1) level measured in a biological sample from the subject greater than a predetermined sTREM-1 value an amount of a TREM-1 inhibitor sufficient to treat the inflammatory disorder.
Claims16
A method of treating septic shock in a human subject in need thereof, the method comprising:
- administering to the subject who has a blood, serum, or plasma concentration above 433 pg/mL of soluble Triggering Receptors Expressed on Myeloid cells-1 (sTREM-1) an effective amount of nangibotide thereby to treat the septic shock.
Dependencies are inferred from the claim text.