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US 12,364,724 B2Granted
Oncolytic virus expressing a car T cell target and uses thereof
AssigneeCity of Hope
InventorsYuman Fong, Saul J. Priceman, Stephen J. Forman, Nanhai Chen, Anthony K. Park
Life of this patent
Estimating the term…
Abstract
An oncolytic poxvirus encoding a truncated human CD19 is used in conjunction with a chimeric antigen receptor to treat solid tumors.
Claims11
A recombinant oncolytic virus comprising a nucleotide sequence encoding a truncated human CD19 lacking a functional signaling domain and comprising the amino acid sequence:
- MPPPRLLFFLLFLTPMEVRPEEPLVVKVEEGDNAVLQCLKGTSDGPTQQLTWSRESPLKP FLKLSLGLPGLGIHMRPLAIWLFIFNVSQQMGGFYLCQPGPPSEKAWQPGWTVNVEGSG ELFRWNVSDLGGLGCGLKNRSSEGPSSPSGKLMSPKLYVWAKDRPEIWEGEPPCVPPRD SLNQSLSQDLTMAPGSTLWLSCGVPPDSVSRGPLSWTHVHPKGPKSLLSLELKDDRPAR DMWVMETGLLLPRATAQDAGKYYCHRGNLTMSFHLEITARPVLWHWLLRTGGWKVS AVTLAYLIFCLCSLVGILHLQRALVLRRKR (SEQ ID NO:
- 29), wherein the nucleotide sequence encoding the truncated CD19 is operably linked to a promoter and is inserted into the J2R locus of an oncolytic virus comprising nucleotide sequence that is at least 99% identical to SEQ ID NO:1, but lacks a sequence encoding thymidine kinase.
Dependencies are inferred from the claim text.