Back to results
US 12,364,609 B2Granted
Biomimetic implants
AssigneeThe Regents of the University of California
InventorsYacov Koffler, Shaochen Chen, Mark Tuszynski, Wei Zhu
Life of this patent
Estimating the term…
Abstract
Implantable devices for spinal cord and peripheral nerve injury are described. The implants include a three-dimensional printed structure having stem cells disposed therein. Also disclosed are methods of treating neuronal injuries with the disclosed implants.
Claims20
A biomimetic nerve or spinal cord implant comprising:
- a three-dimensional (3D) implant body comprising:
- a first end and a second end formed in a biomimetic shape which mimics structure of a nerve or spinal cord injury site as to host axon organization;
- and
- a plurality of linear channels within the body originating at the first end and terminating at the second end, wherein the plurality of linear channels within the body mimics host axon organization ex vivo and in vivo, wherein the plurality of linear channels comprise a channel wall thickness up to 100 micrometers,
- wherein the plurality of linear channels retain their pre-implantation structure for at least 4 weeks in vivo, and
- wherein the implant comprises an elastic modulus from about 260 kPa to about 300 kPa.
3 more elements
Dependencies are inferred from the claim text.