Molecular cryptographic sampling devices and methods of making and using

A molecular cryptographic sampling device, comprising:

• at least one unique identifying indicia disposed on the molecular cryptographic sampling device;
• a substrate including at least one depression disposed in or protrusion disposed on a surface of the substrate;
• at least one polymeric sorbent coating disposed on the at least one depression or protrusion;
• and
• at least one molecular encrypted code disposed on the at least one polymeric sorbent coating, the at least one molecular encrypted code including at least one molecular tag,
• wherein the at least one molecular encrypted code is uniquely associated with the at least one unique identifying indicia in a database or by a predetermined algorithm, and
• wherein the at least one polymeric sorbent coating includes at least two different types of polymeric material on each face of the molecular cryptographic sampling device, and the at least one polymeric sorbent coating is disposed on each face of the molecular cryptographic sampling device.

A molecular cryptographic sampling device, comprising:

• at least one unique identifying indicia disposed on the molecular cryptographic sampling device;
• a substrate including at least one depression disposed in or protrusion disposed on a surface of the substrate;
• at least one polymeric sorbent coating disposed on the at least one depression or protrusion;
• and
• at least one molecular encrypted code disposed on the at least one polymeric sorbent coating, the at least one molecular encrypted code including at least one molecular tag,
• wherein the at least one molecular encrypted code is uniquely associated with the at least one unique identifying indicia in a database or by a predetermined algorithm, and
• wherein the molecular cryptographic sampling device includes a predetermined pattern of at least one of holes and grooves arranged and configured for accumulation of elution solvent and controlled release of the elution solvent onto to the at least one polymeric sorbent coating while the molecular cryptographic sampling device is an orthogonal to mass spectrometer electrospray ionization inlet.

A method for encoding a molecular cryptographic sampling device, comprising:

• determining via a predetermined algorithm a molecular encrypted code to be imprinted on the molecular cryptographic sampling device wherein the at least one molecular encrypted code is uniquely associated with at least one unique identifying indicia by the predetermined algorithm, the molecular cryptographic sampling device including:
• a substrate including at least one depression disposed in or protrusion disposed on a surface of the substrate;
• and
• at least one polymeric sorbent coating disposed on the at least one depression or protrusion;
• transferring molecular encrypted code information to a fluidic system;
• mixing one or more molecular tags by the fluidic system in response to the molecular encrypted code information to form the at least one molecular encrypted code;
• disposing the at least one molecular encrypted code on the at least one polymeric sorbent coating, the at least one molecular encrypted code including the at least one molecular tag;
• and
• disposing the at least one unique identifying indicia on the molecular cryptographic sampling device.

A method for validating a molecular cryptographic sampling device, comprising:

• associating the molecular cryptographic sampling device with an analytical instrument, the molecular cryptographic sampling device comprising:
• at least one unique identifying indicia disposed on the molecular cryptographic sampling device;
• a substrate including at least one depression disposed in or protrusion disposed on a surface of the substrate;
• at least one polymeric sorbent coating disposed on the at least one depression or protrusion;
• and
• at least one molecular encrypted code disposed on the at least one polymeric sorbent coating, the at least one molecular encrypted code including at least one molecular tag,
• wherein the at least one molecular encrypted code is uniquely associated with the at least one unique identifying indicia in a database or by a predetermined algorithm;
• eluting the at least one molecular tag of the at least one molecular encrypted code from the molecular cryptographic sampling device;
• transferring the at least one molecular tag of the at least one molecular encrypted code to the analytical instrument;
• analyzing the at least one molecular tag of the at least one molecular encrypted code with the analytical instrument;
• reading the at least one unique identifying indicia;
• comparing the at least one molecular tag of the at least one molecular encrypted code with the at least one unique identifying indicia via the database or the predetermined algorithm;
• and
• returning a positive value if the at least one molecular tag of the at least one molecular encrypted code corresponds to the at least one unique identifying indicia or a negative value if the at least one molecular encrypted code does not correspond with the at least one unique identifying indicia.