Enzyme immobilized adhesive layer for analyte sensors
AssigneeDexCom, Inc.
InventorsTed Tang Lee, Shanger Wang, Jiong Zou
Life of this patent
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Abstract
Disclosed are devices for determining an analyte concentration (e.g., glucose). The devices comprise a sensor configured to generate a signal associated with a concentration of an analyte and a sensing membrane located over the sensor. The sensing membrane comprises an enzyme layer, wherein the enzyme layer comprises an enzyme and a polymer comprising polyurethane and/or polyurea segments and one or more zwitterionic repeating units. The enzyme layer protects the enzyme and prevents it from leaching from the sensing membrane into a host or deactivating.
Claims30
A device for measurement of a concentration of an analyte, the device comprising:
- a sensor configured to generate a signal associated with the concentration of the analyte in interstitial fluid;
- and
- a sensing membrane located over the sensor, the sensing membrane comprising:
- a first layer, wherein the first layer comprises an enzyme and a first-layer polymer that retains at least 80% of an initial enzyme loading of the enzyme when contacted with an aqueous solution for 1 hour at about 25° C., and wherein the first-layer polymer comprises polyurethane and/or polyurea segments and one or more zwitterionic repeating units, and wherein at least one of the zwitterionic repeating units is an internal zwitterionic repeating unit in a backbone of the first-layer polymer and the at least one of the zwitterionic repeating units compromises a betaine compound or a precursor thereof.
A device for measurement of a concentration of an analyte, the device comprising:
- a sensor configured to generate a signal associated with the concentration of the analyte in interstitial fluid;
- and
- a sensing membrane located over the sensor, the sensing membrane comprising:
- a first layer, wherein the first layer comprises an enzyme and a first-layer polymer that retains at least 50% of initial sensor sensitivity when exposed to 70° C. and 95% relative humidity conditions for up to 24 hours treatment, and the first-layer polymer comprises polyurethane and/or polyurea segments and one or more zwitterionic repeating units wherein at least one zwitterionic repeating unit is an internal zwitterionic repeating unit in a backbone of the first-layer polymer, and the at least one zwitterionic repeating unit comprises betaine compound or a precursor thereof.
Dependencies are inferred from the claim text.