Back to results
US 12,359,217 B2Granted
Virus vector production
AssigneesOspedale San Raffaele S.R.L., Fondazione Telethon Ets
InventorsAlessio Cantore, Andrea Annoni, Michela Milani, Luigi Naldini
Life of this patent
Estimating the term…
Abstract
An enveloped viral particle producer or packaging cell, wherein the cell is genetically engineered to decrease expression of CD47 on the surface of the cell.
Claims18
An enveloped viral particle producer or packaging cell, wherein:
- (a) the producer or packaging cell is genetically engineered to suppress expression of cluster of differentiation 47 (CD47);
- or
- (b) the producer or packaging cell comprises a genetically engineered disruption of a gene encoding CD47,
- to decrease expression of CD47 on the surface of the cell, and
- wherein the producer or packaging cell comprises one or more nucleic acid sequences encoding one or more viral particle structural proteins.
2 more elements
Dependencies are inferred from the claim text.