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US 12,359,191 B2Granted
Polyanionic acids to improve recovery and minimize system loss
AssigneeWaters Technologies Corporation
InventorsMichael Donegan, Martin Gilar, Matthew Lauber, Scott Mccall, Pamela Iraneta, Kerri Smith
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Abstract
The present technology relates to a method of separating a sample comprising oligonucleotides. The method includes injecting a polyphosphonic acid at a concentration of between about 0.01 M to about 1 M into the sample comprising oligonucleotides. The method also includes flowing the sample and polyphosphonic acid through a liquid chromatography column and separating the oligonucleotides.
Claims13
A method of separating a sample comprising oligonucleotides comprising:
- injecting a polyphosphonic acid at a concentration of between about 0.01 M to about 1 M into the sample comprising oligonucleotides;
- flowing the sample and polyphosphonic acid through a liquid chromatography column;
- and
- separating the oligonucleotides.
1 more element
Dependencies are inferred from the claim text.