Transthyretin antibodies and uses thereof
AssigneeMor Research Applications Ltd.
InventorsMichael Fassler, Jacob George
Life of this patent
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Abstract
The present disclosure provides antibodies and antigen-binding fragments thereof that specifically bind to human transthyretin (TTR). The anti-TTR antibodies or antigen-binding fragments thereof are useful, for example, in detecting TTR and in treating TTR amyloidosis in a subject.
Claims20
An antibody or antigen-binding fragment thereof capable of binding human transthyretin (TTR), wherein the antibody or antigen-binding fragment thereof comprises a complementary determining region (CDR) H1 comprising the amino acid sequence set forth in SEQ ID NO:
- 8, a CDR H2 comprising the amino acid sequence set forth in SEQ ID NO:
- 9, a CDR H3 comprising the amino acid sequence set forth in SEQ ID NO:
- 10, a CDR L1 comprising the amino acid sequence set forth in SEQ ID NO:
- 11, a CDR L2 comprising the amino acid sequence set forth in SEQ ID NO:
- 12, and a CDR L3 comprising the amino acid sequence set forth in SEQ ID NO:
- 6.
An antibody or antigen-binding fragment thereof capable of binding human TTR, wherein the antibody or antigen-binding fragment comprises a VH comprising the same amino acid sequence as the VH of the antibody produced by the hybridoma of ATCC® deposit number PTA-125005 and a VL comprising the same amino acid sequence as the VL of the antibody produced by the hybridoma of ATCC® deposit number PTA-125005.
A method for increasing the uptake of TTR aggregates by an immune cell exposed to TTR aggregates comprising contacting the immune cell with an antibody or antigen-binding fragment that binds TTR, wherein the antibody or antigen-binding fragment competitively inhibits an antibody comprising the VH sequence of the antibody produced by the hybridoma of ATCC® deposit number PTA-125005, and the VL sequence of the antibody produced by the hybridoma of ATCC® deposit number PTA-125005 from binding to TTR.
Dependencies are inferred from the claim text.