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US 12,358,922 B1Granted
Berberine alpha-ketoglutarate salt, crystalline form, methods of preparation and applications thereof
AssigneeLongevitan Biosciences LLC
InventorsDedong Wu, Branden Wu, Jacob Dongjian Shi
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Abstract
The present disclosure relates to berberine alpha-ketoglutarate salts, which can be used in a pharmaceutical or nutraceutical composition for the treatment or prevention of bacterial infections, cardiovascular diseases, or other conditions. The present disclosure also relates to crystalline forms, methods of preparing berberine alpha-ketoglutarate salts and applications thereof.
Claims15
A berberine alpha-ketoglutarate salt in solid form having any one of the following chemical formulas:
A single crystalline form of a berberine alpha-ketoglutarate salt that exhibits the following PXRD characteristics:
- triclinic P-1 space group, Z′=2, unit cell dimensions:
- a=11.7475(5) Å, b=14.2681(6) Å, c=15.2790(6) Å, α=101.394(1)°, β=102.756(1)°, γ=112.146(1)° and V=2198.9(2) Å3.
Dependencies are inferred from the claim text.