Urolithin derivatives and methods of use thereof

A compound of Formula (Ia):

• wherein
• A is
• X1 is O;
• Y1 is O;
• R1, R4, R5 and R8 are independently selected from H and halogen;
• R3 and R6 are independently selected from H, CN, OH, CF3, halogen, and alkyl;
• R2 is OH;
• and R7 is alkynyl-R9;
• R9 is selected from OH, O-alkyl, NHSO2-alkyl, N(CH3)SO2-alkyl, unsubstituted or substituted cycloalkyl, and unsubstituted or substituted heterocycloalkyl;
• and
• each cycloalkyl or heterocycloalkyl, when substituted, is substituted with alkyl, halogen, hydroxyl, carboxyl, thiocarbonyl, alkoxy, amino, amido, amidine, an imine, cyano, nitro, sulfhydryl, alkylthio, sulfate, sulfonate, sulfamoyl, sulfonamido, heterocyclyl, and/or aralkyl;
• or a pharmaceutically acceptable salt thereof.