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US 12,358,870 B2Granted
Solid dispersions and pharmaceutical compositions comprising a substituted indane and methods for the preparation and use thereof
AssigneePeloton Therapeutics, Inc.
InventorsChristopher Lindemann, Peter J. Stengel
Life of this patent
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Abstract
Provided herein are solid dispersions comprising a HIF-2α inhibitor, pharmaceutical compositions comprising the solid dispersions, and methods for treating HIF-2α-mediated diseases and conditions.
Claims12
A pharmaceutical solid dosage form for oral delivery of a compound of Formula (I),
- wherein the solid dosage form comprises
- a solid dispersion comprising the compound of Formula (I), a pharmaceutically acceptable polymer selected from the group consisting of Hypromellose acetate succinate (HPMCAS), cellulose acetate phthalate (CAP), and polyethylene glycol vinyl acetate vinylcaprolactam,
- one or more pharmaceutically acceptable excipients comprising a binder, a filler, a disintegrant and a lubricant,
- wherein the binder is a microcrystalline cellulose, and
- the solid dosage form is a capsule or a tablet.
2 more elements
Dependencies are inferred from the claim text.