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US 12,358,869 B2Granted
Diarylureas as CB1 allosteric modulators
AssigneeResearch Triangle Institute
InventorsYanan Zhang, Thuy Nguyen, Nadezhda German
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Abstract
The present invention provides novel diarylurea derivatives (compounds of formula (I)) and their uses. The compounds of the present invention are demonstrated to be allosteric modulators of the CB1 receptor, and therefore useful for the treatment of diseases and conditions mediated by CB1.
Claims4
A compound of formula:
A compound of formula (I):
- wherein:
- R1 is azetidine, optionally substituted with one or more R2;
- R2 is H, C1-6 alkyl C1-6 alkenyl, C1-6 alkynyl, C1-6 alkoxy, halogen or 5- to 13-membered aryl;
- or a pharmaceutically acceptable salt or solvate thereof.
1 more element
Dependencies are inferred from the claim text.