Nitrogen-containing derivative of substituted phenol hydroxy acid ester, and preparation and use thereof
AssigneeWest China Hospital, Sichuan University
InventorsJun Yang, Jin Liu, Weiyi Zhang
Life of this patent
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Abstract
A nitrogen-containing derivative of substituted phenol hydroxyl acid ester is represented by formula (I). A salt of the compound of formula (I) has good water solubility, and in vivo, can rapidly and completely release substituted phenols having a pharmacological effect, which can improve the water solubility of substituted phenols, rapidly exert the pharmacological effects of substituted phenols in vivo, and has good safety. The method for preparing the above-mentioned compound is provided. This compound can also be used in the preparation of drugs that produce anaesthesia and/or sedative and hypnotic effects on humans and animals.
Claims10
A compound of formula (I):
- wherein:
- R1-R5 are each independently selected from H, C1-6 linear or branched or cyclic hydrocarbyl, halogen, C1-4 alkoxy, cyano, nitro, ester group,
- R6-R9 are each independently selected from H, and C1-8 linear or branched or cyclic hydrocarbyl, or R6 and R7, or R7 and R8 are optionally covalently linked to form a cyclic hydrocarbyl;
- H in the skeleton of R1-9 are unsubstituted or substituted with a group selected from halogen, hydroxyl, sulfhydryl, carbamoyl, guanidyl, carboxyl, 4-imidazolyl, phenyl, hydroxyphenyl, and β-indolyl;
- R1-9 skeleton optionally contains one or more heteroatoms selected from O, S, and N;
- and
- with provisos that:
- R6 and R7 are not simultaneously H, and when R7 and R8 are covalently linked, R7 and R8 are independently selected from C1-3 alkylenes.
Dependencies are inferred from the claim text.