Cell delivery system and methods of operation thereof
AssigneeSanBio, Inc.
InventorMichael McGrogan
Life of this patent
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Abstract
A method of preparing a syringe in connection with a therapeutic treatment is disclosed. The method can include removing a plunger of the syringe from a barrel of the syringe, aligning the barrel in a horizontal orientation, filling a lumen of the barrel with a viscous material through an opening at a proximal end of the barrel, and inserting a plunger tip into the lumen to seal the lumen. The method can also include attaching an implantation device to a hub coupled to the barrel at a distal end of the barrel. The method can also include depressing the plunger until the cell suspension fills the implantation device and a droplet of the cell suspension is expelled from a distal tip of the implantation device.
Claims14
A method of treating a traumatic brain injury in a subject, the method comprising:
- removing a plunger of a syringe from a barrel of the syringe, wherein the barrel has a proximal end, a distal end, and a lumen in between the proximal end and the distal end;
- filling at least part of the lumen with a cell suspension comprising a therapeutically effective amount of cells through an opening at the proximal end and reinserting the plunger, wherein the cells are descendant from mesenchymal stem cells transiently-transfected by a polynucleotide encoding a Notch intracellular domain;
- coupling an implantation device to the syringe at the distal end of the barrel;
- injecting the cell suspension into the subject using the syringe and the implantation device at multiple deposit sites in the subject;
- and
- rotating at least one of the syringe and the implantation device about a longitudinal axis after each injection at a deposit site of the multiple deposit sites.
Dependencies are inferred from the claim text.