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US 12,357,748 B2Granted
Microdosing
AssigneeHoffmann-La Roche Inc.
InventorsMichael Adler, Joerg Luemkemann, Hanns-Christian Mahler, Denis Luthringer, Alexander Meyer, Adeline Boillon, Anke Dorn, Karoline Bechthold-Peters, Tim Dreckmann, Andreas Ernst
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Abstract
A dosing system for transferring an aseptic fluid in dosages into a container, comprising a peristaltic pump configured such that the filling accuracy for fill volumes of the aseptic fluid<100 μL is ±3 μL.
Claims20
A dosing system for transferring an aseptic fluid in dosages into a container, comprising:
- a peristaltic pump with a tubing,
- a liquid flow measurement sensor, and
- a control unit,
- wherein the peristaltic pump is configured to provide a filling accuracy of ±3 μL for fill volumes of the aseptic fluid of less than 100 μL by
- the tubing having an internal diameter of between 1.6 mm and 0.8 mm,
- the liquid flow measurement sensor being connected to the peristaltic pump and configured to report a volume of the aseptic fluid passed through the peristaltic pump, wherein the liquid flow measurement sensor is a capacitive pressure sensor, and
- the control unit being coupled to the peristaltic pump and coupled to the liquid flow measurement sensor, wherein the control unit is configured to receive a data signal from the liquid flow measurement sensor, to evaluate the received data signal, and to adapt the peristaltic pump in accordance with the evaluated data signal.
4 more elements
Dependencies are inferred from the claim text.