Optimized CYP4V2 gene and application thereof
AssigneeSuzhou Nggt Biotechnology Co., Ltd.
InventorsQing Cao, Hai Zhang, Shengmei Wen, Lixin Jiang
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Abstract
Provided are an optimized CPY4V2 gene and an application thereof. The gene relates to a polynucleotide for coding a CYP4V2 protein, and comprises a nucleotide sequence having 90% or over 90% of identity with a nucleotide sequence as shown in SEQ ID NO: 5, SEQ ID NO: 6, SEQ ID NO: 7, SEQ ID NO: 8 or SEQ ID NO: 9. Also provided is an expression vector comprising the gene. The expression vector can realize lasting and stable expression in retinal pigment epithelium of eyes, can effectively reduce the dosage and possible side effects of a gene therapy drug for treating BCD, and improves the therapeutic effect.
Claims64
A polynucleotide encoding a CYP4V2 protein, wherein the polynucleotide comprises the nucleotide sequence as shown in SEQ ID NO:
- 5.
Dependencies are inferred from the claim text.