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US 12,357,674 B2Granted
Methods for promoting wound healing and hair growth comprising GDNF administration
AssigneeThe Jackson Laboratory
InventorsRobert E. Braun, Manju Sharma
Life of this patent
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Abstract
The present invention generally relates to uses of glial cell line-derived growth factor (GDNF) in cutaneous wound healing and hair growth. Methods of effecting hair growth and/or wound healing which feature administration of GDNF, or a biologically active fragment thereof, to subjects, e.g., human subject, are disclosed herein. The invention relates also to formulations and kits for achieving the indicated pharmaceutical advantages.
Claims18
A method for promoting hair growth comprising:
- administering to skin comprising hair follicles of a subject in need thereof a therapeutically effective amount of a topical formulation comprising recombinant human glial cell-derived neurotrophic factor (GDNF), wherein the therapeutically effective amount increases the number of hair follicles in the skin of the subject.
A method for promoting hair growth comprising:
- administering to the scalp of a subject a therapeutically effective amount of a topical formulation comprising recombinant human glial cell-derived neurotrophic factor (GDNF), wherein the therapeutically effective amount increases the number of hair follicles in the scalp of the subject, and wherein the subject has androgenetic alopecia.
A method for promoting hair growth comprising:
- administering to the scalp of a subject a therapeutically effective amount of a topical formulation comprising recombinant human glial cell-derived neurotrophic factor (GDNF), wherein the therapeutically effective amount increases the number of hair follicles in the scalp of the subject, and wherein the subject has acute or chronic telogen effluvium.
Dependencies are inferred from the claim text.