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US 12,357,638 B2Granted
Immunoproteasome inhibitor formulations
AssigneeKezar Life Sciences
InventorEvan Lewis
Life of this patent
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Abstract
Provided herein are pharmaceutical formulations comprising KZR-616 or a salt thereof, and a sugar, wherein the formulations are lyophilized, methods of preparing said formulations, methods of treating immune-related diseases, and methods of treating inflammation.
Claims16
A pharmaceutical formulation comprising KZR-616 maleate salt, and a sugar comprising trehalose, wherein KZR-616 has a structure
- and the formulation is a lyophilized formulation that upon reconstitution, has a pH of 3.8 to 4.3 and a concentration of 1.5 wt % to 5 wt % trehalose.
Dependencies are inferred from the claim text.