Nanocarriers and their processing for diagnostics and therapeutics
AssigneeRhode Island Hospital
InventorsQian Chen, Yupeng Chen, Hongchuan Yu, Michael G. Ehrlich
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Abstract
The compositions and methods of the invention provide compositions and methods for preferential targeting of tissues to delivery therapeutic or diagnostic agents. For example, such compounds are useful in the treatment of joint disorders those affecting articulating joints, e.g., injury-induced osteoarthritis as well as autoimmune diseases affecting joint tissue such as rheumatoid arthritis.
Claims7
A method of treating a disease or disorder of the central nervous system comprising administration of an effective amount of a nanopiece, wherein said nanopiece comprises a compound of Formula I or Formula II or a combination thereof, and a nucleic acid:
- wherein,
- X is CH or N;
- R2 is hydrogen or a linker group;
- Y is absent when R2 is hydrogen or is an amino acid side-chain, amino acid or polypeptide;
- and
- R1 is hydrogen or C1 to C10 alkyl;
- and
- wherein the nanopiece has a size in at least one dimension between 1 nm and 30 nm,
- wherein a ratio of the compound to nucleic acid ranges from 4.4 to 30 μg compound per to 0.1 nmol of the nucleic acid,
- wherein the nanopiece is positively charged at pH 7-7.5.
Dependencies are inferred from the claim text.