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US 12,357,626 B2Granted
Anthranilic acid-based compound, and Pin1 inhibitor, therapeutic agent for inflammatory diseases and therapeutic agent for cancer that use the same
AssigneeAmenis Bioscience, Inc.
InventorsTomoichiro Asano, Yusuke Nakatsu, Hisanaka Ito, Takayoshi Okabe
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Abstract
The purpose of the invention is to develop, as drug-candidate compounds, a group of novel compounds having the activity of inhibiting functions of Pin1. The invention provides: a compound represented by formula (I) or a salt thereof; and a Pin1 inhibitor, a pharmaceutical composition, a therapeutic or prophylactic agent for inflammatory diseases, a therapeutic or prophylactic agent for cancer, and a therapeutic or prophylactic agent for adiposity that use said compound/salt.
Claims24
A compound represented by the Formula (I), or a salt thereof:
- wherein at least one of the R1 or R2 represents an optionally substituted naphthyl group, an optionally substituted quinolyl group, or an optionally substituted phenoxy phenyl group;
- either R1 or R2 represents, if not any of the above-described groups, an optionally substituted aryl group, or an optionally substituted monocyclic heterocyclic group;
- R3 represents a hydrogen atom, an optionally substituted hydrocarbon group, or an optionally substituted heterocyclic group;
- and
- X represents a single bond, —CO— group, —CO—O—CH2— group, —CO—CH2—O— group, —SO2— group, —CH2—CO—NH— group, —CH2—CO— group, or —CH2— group.
2 more elements
Dependencies are inferred from the claim text.