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US 12,357,582 B2Granted
Hydrophobic ion pairing and flash nanoprecipitation for formation of controlled-release nanocarrier formulations
AssigneeThe Trustees of Princeton University
InventorsRobert K. Prud'homme, Kurt D. Ristroph, Nathalie M. Pinkerton, Hoang D. Lu, Paradorn Rummaneethorn
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Abstract
Methods for encapsulating water-soluble biologic and small molecule active pharmaceutical ingredients (APIs) into nanoparticles by applying nanoprecipitation techniques and ion-pairing the nanoparticles with hydrophobic counterions to produce new API salts that exhibit altered solubilities are presented.
Claims16
A set of nanoparticles, comprising:
- nanoparticles comprising
- a modified salt comprising an active pharmaceutical ingredient (API) ion paired with a hydrophobic counterion;
- and
- a nanoparticle encapsulant material substantially surrounding the modified salt,
- wherein the nanoparticle encapsulant material comprises polycaprolactone-block-polyethylene glycol block copolymer (PCL-b-PEG),
- wherein the active pharmaceutical ingredient (API) is a water-soluble linear cationic peptide of a molecular weight of from 1,422 Da to 2,000 Da and of at least 14% basic amino acids of amino acids,
- wherein the hydrophobic counterion is an alkyl sulfate, and
- wherein the set of nanoparticles has a Z-average diameter of at least 120 nm.
5 more elements
Dependencies are inferred from the claim text.