Composition for treating or preventing skin pigmentation

A method for treatment of skin pigmentation of a subject in need thereof, the method comprising:

• applying fibroblasts as an active ingredient to a site of skin pigmentation or a surrounding dermal tissue of the subject, wherein:
• the fibroblasts are fibroblasts with less damage than fibroblasts localized at the site of skin pigmentation,
• the fibroblasts have lower expression of a cell senescence marker than fibroblasts localized at the site of skin pigmentation,
• the fibroblasts are derived from a tissue selected from the group consisting of a gluteal region, an abdominal region, a thorax, a femoral region, an upper arm, a dorsal region, a gingiva, an oral mucosa, a scalp, and an auricle rear,
• the cell senescence marker is one or more selected from the group consisting of senescent acidic β-galactosidase (SA-βgal), cell cycle check mechanism-associated factor and cell senescence-associated secretory phenotype (SASP) factor, and
• the skin pigmentation is caused by activated melanocytes induced by photo damaged-fibroblasts.