System and method of treatment of bone lesions

A method of treating a bone marrow lesion, the method comprising:

• drilling, using a drilling system, a subchondral channel into a bone, the drilling system comprising:
• a drill guide having a first cannula with a proximal end and a distal end;
• a wire guide having a second cannula with an outer diameter adapted to fit within the first cannula of the drill guide and further configured with a length that extends from an area proximate to an injury site to beyond the proximal end of the drill guide;
• a guide wire with diameter configured to fit within the second cannula and to extend from the injury site beyond a proximal end of the wire guide;
• a drill device having an outer diameter configured to fit within the first cannula and comprising:
• a third cannula extending through the drill device;
• a head portion at a proximal end of the drill device, the head portion comprising a Jacobs-Chuck and luer fitting;
• and
• a bit at a distal end of the drill device and comprising a hollow configured to allow the guide wire to pass therethrough;
• providing a cellular component to the injury site by injecting the cellular component through the third cannula of the drill device, the cellular component comprising autologous adipose tissue that has been filtered, enzymatically digested, and or concentrated to isolate progenitor cells at a concentration greater than 1.1× than natural adipose fluid and to remove adipocytes and connective tissue;
• and
• injecting a retention medium into the injury site via a syringe connected to the luer fitting to promote retention of the cellular component at the injury site.